Ultra-low volume Dispensing Systems: The Cutting-Edge Technology for POC Manufacturing
Point of care tests are medical tests that can be performed directly at the point of patient care without requiring analysis in a central laboratory. They enable rapid and accurate diagnosis of various diseases and conditions, such as infections, diabetes, cardiovascular diseases, or cancer. Point of care tests have many advantages for medicine, both for patients and physicians. The use of these technologies enables care that would otherwise not be possible due to a lack of laboratory tests. This not only improves the quality of care but also reduces costs, increases efficiency, and expands access.
To manufacture point of care tests, special technologies and systems are required that allow specific reagents to be pre-stored with high precision and contact-free dosing of small amounts of liquids onto various substrates in a precise and reproducible manner.
This is important for the quality and performance of point of care tests. Hamilton Freiburg offers innovative solutions such as the PIPEJET® nanoDispenser or the BIOSPOT® workstation to solve some of the biggest challenges in the production of point of care tests: automating and simplifying the manufacturing process, improving product quality, and reducing production costs.
On this page, we will explain how the technology offered by Hamilton Freiburg contributes to innovative development of diagnostic POC tests and how efficient production of these tests can be implemented.
As part of the Hamilton family, Hamilton Freiburg provides the most precise and accurate liquid dispenser technology. With unique solutions tailored to your application, you can automate your workflows. Liquid-independent, contactless, production-optimized, and limitless.
What is a Point of Care System and how does it work?
A Point of Care System (POC system) is a medical testing procedure that can be used directly at the point of patient care without requiring analysis in a central laboratory. It enables rapid and accurate diagnosis of various diseases and conditions, such as infections, diabetes, cardiovascular diseases, or cancer. A Point of Care System can also be used for monitoring the health status of patients or adjusting therapies.
Speed: Compared to traditional laboratory methods, which typically require complicated sample collection, sample preparation, and long wait times, POC systems are capable of delivering results within minutes. This allows for rapid and effective decision-making regarding diagnoses and treatments.
Flexible: POC systems are typically very compact and portable, allowing them to be used in various locations. There are different types of POC systems that are used depending on the type of tests and the required precision. POC system technology is constantly being developed to achieve even more precise results.
A Point of Care System can use various technologies to detect and analyze the biological sample. Some examples include:
- Immunochromatography: A method that relies on the specific binding of antibodies to antigens. It is often used for pregnancy tests or HIV tests.
- Biosensors: A method that relies on the use of biological molecules (such as enzymes or DNA) that trigger a physicochemical change or chemical reaction when in contact with the sample. It is often used for glucose or cholesterol measurements.
- Microfluidics: A method that relies on the manipulation of small amounts of liquids in microscopic channels. It is often used for DNA analysis or cell counting.
A Point of Care System is an important tool for 21st century medicine. It provides an innovative solution to some of the biggest challenges facing healthcare: improving quality, reducing costs, and expanding access to care.
Hamilton Freiburg is the perfect partner for manufacturers seeking innovative dosing solutions for point-of-care testing. Our customized droplet dispensing systems are tailored to the specific needs of diagnostic manufacturers and are characterized by the highest precision and reliability.
The benefits of Point of Care Systems for medicine
Point of Care Systems (POC systems) play an important role in medicine, as they enable clinical tests to be performed quickly and effectively. This is particularly important in situations where a rapid diagnosis and treatment is required. POC systems allow medical personnel to make diagnoses on-site instead of having to send samples to a remote laboratory. This enables diagnoses to be made faster and treatments to be initiated immediately.
Efficiency: By using POC systems and miniaturizing samples, costs can also be saved as the process of sample collection and transport to a remote laboratory is eliminated. Additionally, POC systems enable closer collaboration between doctors and patients, as they allow medical personnel to interact directly with patients on-site and provide them with a rapid diagnosis and treatment.
Speed: The importance of POC systems is also evident in emergencies, where it is often a matter of minutes or seconds. In these situations, a rapid and accurate test can be crucial to saving lives and ensuring the correct treatment. POC systems can also be used in remote areas where traditional laboratory methods are not available.
Therefore, Point of Care Systems offer many benefits for medicine, both for patients and doctors. Some of these include:
- They improve the quality of care by enabling timely and precise diagnosis, which can lead to earlier treatment and better prognosis.
- They reduce the costs of care by avoiding unnecessary transports, waiting times, or retesting, and optimizing resource consumption.
- They increase the efficiency of care by reducing the workload and error rate of medical professionals and giving them more time to interact with patients.
- They expand access to care by being used in different environments, such as rural areas, developing countries, or crisis situations.
- They can be applied by the patient for preliminary examination.
The customized dosing system solutions from Hamilton Freiburg support the development of Point of Care tests and help diagnostic manufacturers to fully exploit the benefits of this innovative technology, such as process speed and miniaturization of sample volumes.
Applications
Point of Care Systems in Practice: Applications, Examples, and Experiences
POC systems are used in many different application areas to enable rapid and precise diagnoses. In practice, they are mainly used in emergency medicine, primary care, intensive care, and geriatrics.
In emergency medicine, POC tests enable rapid diagnosis directly on site. This ensures faster treatment and care for the patient. In primary care, POC tests can be used for many different diseases and complaints to enable rapid diagnosis and treatment.
In intensive care medicine, POC tests play an important role in monitoring patients who need to be examined regularly due to their health condition. Here, POC tests enable continuous monitoring and diagnosis without the need for patients to be sent to the laboratory.
Point of care systems are also used in geriatrics. Especially older patients often have difficulties coming to the laboratory. Here, POC tests can enable a rapid and uncomplicated diagnosis, which can also be performed directly on site.
The diverse application areas of POC tests make them an important technology for medical diagnostics.
Point of Care Systems vs. Laboratory Methods: The 5 Key Advantages
Traditional laboratory methods are often very complex and time-consuming. In comparison, Point of Care Systems offer many advantages that enable faster diagnosis and treatment.
Speed
One of the biggest advantages of POC tests is their speed. They can be performed directly on site, with results typically available within minutes. In contrast, traditional laboratory tests often require sending samples to the lab, which can take several days.
Flexibility
Another advantage of Point of Care Systems is their mobility. POC tests can be performed in the doctor's office, hospital, or even at the patient's home. This allows for faster diagnosis and treatment without the patient needing to go to the lab or hospital.
Efficiency
Point of Care Systems increase the efficiency of care by reducing the workload and error rate of medical professionals, allowing them more time to interact with patients. They also improve communication and coordination between different stakeholders in the care chain, such as doctors, nurses, pharmacists, or lab technicians.
Access
In different scenarios, such as in remote areas, low-income countries, or during crises, Point of Care Systems can improve care. They also overcome some barriers to accessing care, such as lack of infrastructure, personnel, or equipment.
Costs
In terms of costs, POC tests also offer advantages. Since they can be performed on site, expensive transportation costs for samples are eliminated. In addition, POC tests can reduce or even replace the need for expensive laboratory tests, saving costs.
The precise dosing technologies of Hamilton Freiburg support diagnostic manufacturers in optimally leveraging the advantages of Point of Care Systems. With flexible applicability, precise and reliable dosing of liquids, and intuitive programming of devices, new POC tests can be developed quickly and effectively. New, innovative tests not only improve the quality of care, but also reduce costs and increase efficiency. With tailored solutions and innovative products, Hamilton Freiburg offers the perfect complement to the development of Point of Care tests.
Types and Structure of Point of Care Tests
A capillary test, also known as a lateral flow test, consists of a nitrocellulose test strip that is coated with a combination of reagents. The sample is applied to the sample pad of the test strip and then transported along the test strip by capillary action. When the sample interacts with the reagents in the test strip, a visible color change or other visual indicator may occur, indicating the presence or absence of the analyte being tested for. The test strip consists of various components such as a sample pad, a conjugate pad, a test line, a control line, and an absorption pad.
A microfluidic test consists of a microfluidic chip that is equipped with tiny channels and chambers into which the sample is introduced. The sample is moved through the channels by pressure or centrifugal actuation. The chip is coated with special reagents that react to the compound being tested and generate a signal when it is present. The signal can be detected by various methods such as color changes, fluorescent and optical measurements or electronic sensors.
There are other test methods in point-of-care diagnostics, but capillary tests, standard test strips and microfluidic tests are among the most well-known and widely used methods.
The advancing miniaturization of diagnostic tests has required increasingly precise dosing of liquids. Hamilton Freiburg offers tailor-made solutions specifically designed to meet the requirements of point-of-care test production. The precise dosing systems from Hamilton Freiburg enable reliable and accurate dosing of small volumes that are critical for the diagnosis and treatment of patients.
As a leading provider of dosing solutions, Hamilton Freiburg offers a wide range of dosing systems ranging from traditional dosing to complex automated systems . Thanks to the precise dosing technology of Hamilton Freiburg, medical manufacturers can make even more effective use of the benefits of point-of-care testing and raise their products to a higher quality level.
Dispensing systems for POC: How they improve the quality and performance of Point of Care tests
As an expert in ultra-precise dosing systems, we at Hamilton Freiburg understand the importance of proper liquid dosing in the production of Point-of-Care tests. Our tailored solutions are specifically designed to meet the requirements of these tests by our reliable and accurate dosing capabilities of small liquid volumes.
With our dispensing systems , diagnostic manufacturers can improve the quality and performance of their Point-of-Care tests, thereby enabling faster and more accurate diagnosis. Precision and reliability are key to the successful execution of medical tests, and that is exactly what we offer with our dosing systems.
Our dosing systems offer a versatile range of application possibilities, from simple dosing to highly complex, automated systems that guarantee the highest efficiency and productivity.
As a manufacturer of high-precision dosing solutions for the smallest amounts of liquids, we are committed to helping our customers further expand the benefits of Point-of-Care tests and elevate their products to a higher level. We are proud to be a reliable partner for the medical industry and work together to create better care for patients.
BioFluidix dispensing systems enable ultra-precise dispensing of liquids, even in the smallest volumes. With highest accuracy down to the picoliter range, diagnostic manufacturers can rely on the highest precision in the production of point-of-care tests.
Our dispensing systems are designed for precise dispensing of the smallest amounts of liquid, enabling high accuracy and reproducibility while achieving extremely high dispensing speeds. This allows our customers to work quickly and reliably even with large quantities, producing their products at the highest level.
BioFluidix's innovative technologies enable flexible automation of laboratory processes, including handling of small liquid volumes in the picoliter, nanoliter and microliter range. Our customized solutions enable automation of specific applications based on the BIOSPOT® platform. This increases efficiency, standardization and overall quality of the laboratory workflow, allowing for higher throughput and miniaturization of workflows.
Our dispensing systems not only enable precise dispensing and fast throughput times, but also significant material and cost savings. The precise dispensing of the smallest amounts of liquid reduces material waste, leading to cost savings.
Technology
Technology of Point of Care Tests
Point-of-care tests (POC tests) are diagnostic tests that are performed at the point of care, rather than in a central laboratory. This enables fast diagnoses and effective treatment in real-time. The technology behind POC tests varies depending on the application and can be based on different principles, such as immunological, molecular, or biochemical methods.
A common example of a POC technology is the lateral flow test, in which a sample is applied to a test strip that contains various reagents. If certain molecules or antigens are present in the sample, they react with the reagents on the test strip, producing a visible color change. Another example is microfluidic systems, which rely on the use of tiny channels and microchannels to precisely transport and mix liquids.
However, to fully harness the benefits of POC tests, these technologies need to be combined with precise and reliable dosing systems to apply the right amount of liquid and reduce the risk of errors or deviations in test results.
Hamilton Freiburg contributes to improving material and cost savings in POC tests by offering ultra-precise dosing systems. With our innovative BIOSPOT® platform, we can develop customized solutions for automating test processes with precise dosing of small amounts of liquid. Automation reduces the risk of human error and increases efficiency and throughput, resulting in higher productivity and quality.
Technological developments in the field of Point of Care
In recent years, many technological developments have emerged in the field of Point of Care, and the COVID-19 pandemic has further highlighted the importance of technology. In particular, new opportunities have arisen with regard to miniaturization and automation. Today, it is possible to develop compact systems that enable rapid and precise diagnosis directly at the patient's bedside, using sensor technologies and innovative detection methods, for example.
An important development is the combination of Point of Care tests with digital technology. By integrating data processing and wireless transmission, POC tests can be evaluated and interpreted in real time. This enables medical professionals to diagnose and treat more quickly and accurately. The use of cloud platforms for data recording and analysis also opens up new opportunities in personalized medicine.
Another advantage of Point of Care tests is their disposable nature. This allows for quick and easy diagnosis without the need for complex cleaning or disinfection. Furthermore, the use of disposable items reduces the risk of cross-contamination
Hamilton Freiburg is a strong partner for companies developing innovative Point of Care systems. With their customizable and precise dosing systems and extensive experience in liquid dosing miniaturization, Hamilton Freiburg can help develop pioneering solutions for Point of Care diagnostics.
Market
The current market situation and future prospects
Point-of-care tests have gained importance in recent years and are used in many areas of medicine. The market for point-of-care testing is expected to continue to grow as more medical facilities rely on fast and reliable diagnostic procedures. The COVID-19 pandemic has intensified this trend and increased the demand for point-of-care testing. The global market for point-of-care tests is expected to reach a volume of over $80 billion by 2029 (Source: Point of Care Diagnostics Market Size & Growth Report [2022-2029] (fortunebusinessinsights.com)).
The market for POC tests is divided into various segments such as pregnancy tests, infectious disease tests, diabetes tests, and cancer tests. Infectious disease tests are currently the largest segment in the point-of-care test market. The increase in the prevalence of infectious diseases and the need for fast diagnostic procedures are the main drivers for the growth of this segment.
Europe and North America are currently the largest markets for point-of-care testing. However, the market in the Asia-Pacific region is expected to grow the fastest as governments in this region increase their investment in healthcare and demand for POC testing increases. There is also high potential in developing countries as POC tests represent a cost-effective alternative to conventional laboratory tests.
The market for POC tests is divided into various segments such as pregnancy tests, infectious disease tests, diabetes tests, and cancer tests. Infectious disease tests are currently the largest segment in the point-of-care test market. The increase in the prevalence of infectious diseases and the need for fast diagnostic procedures are the main drivers for the growth of this segment.
Europe and North America are currently the largest markets for point-of-care testing. However, the market in the Asia-Pacific region is expected to grow the fastest as governments in this region increase their investment in healthcare and demand for POC testing increases. There is also high potential in developing countries as POC tests represent a cost-effective alternative to conventional laboratory tests.
The COVID-19 Pandemic
The COVID-19 pandemic has led to a tremendous increase in demand for POC tests, which enable fast and accurate detection of the virus. In particular, molecular POC tests based on the amplification and detection of nucleic acids have proven to be very useful in containing the spread of the virus. In addition, many people have turned to self-medication practices, especially during the COVID-19 outbreak, as self-test kits provided quick results in the home setting.
Technological Innovations
Technological innovations have contributed to improving the quality, accuracy, and availability of POC tests. Some of the latest technological developments in the field of POC include:
Genomics and Precision Medicine
Genomics and precision medicine are approaches that allow POC tools and devices to be personalized for individual patients based on their genetic and molecular profiles, to ensure optimal diagnosis, treatment, and therapy monitoring.
Microfluidics and Instrumentation
Microfluidics and instrumentation are technologies that enable manipulation, analysis, and measurement of small amounts of samples. These technologies are increasingly being used in medical diagnostics and research as they offer high precision, sensitivity, and speed. By combining microfluidics and instrumentation with ultra-precise dispensing systems such as the BIOSPOT® platform, diagnosis and therapy decisions can be made faster and more accurately, which can be crucial for acute illnesses. Furthermore, the personalization of patient sample analysis through these technologies allows for targeted and effective treatment tailored to the individual needs and characteristics of each patient.
The POC test market offers many opportunities for growth and innovation, but it also requires constant adaptation to the changing needs of patients and healthcare providers. With innovative and reliable solutions and the most precise drop dispenser products, BioFluidix offers medical manufacturers a wide range of options to meet the demanding requirements of the market. Process control systems such as our SmartDrop system or the TopView camera enable highly precise and reproducible quality control during the instrumentation of microfluidic systems.
Sources:
Point of Care Testing Market Share Forecasts 2022-2030 (gminsights.com)
Point of Care Diagnostics (POCD) Market | Current Scenario and Future Aspect Analysis with Top Countries Data - MarketWatch
Point of Care Diagnostics Market Size & Growth Report [2022-2029] (fortunebusinessinsights.com)
Revolutionary Technology: How Ultra-Precise Droplet Dispensing Systems will Change the Medical Landscape
Precise dispensing systems for small liquid volumes from Hamilton Freiburg have the potential to change the way medical tests and diagnoses are carried out. Our devices enable higher accuracy, speed, and reproducibility by applying precise and reproducible dosages of liquids to various substrates for POC tests.
In addition, dispensing systems can also be used in conjunction with other groundbreaking technologies to further advance the medicine of the future.
Artificial intelligence (AI) can be used in medicine to network and analyze patient data, individualize and optimize treatment processes, and support diagnoses and therapies.
Modern dispensing systems can benefit from AI by automatically adjusting the optimal dosing parameters for different tests or detecting and correcting errors.
Robot-assisted surgery is the use of robots or computer-controlled instruments to perform operations. This technology allows for higher precision, speed, and safety, as well as lower invasiveness and complication rates.
Droplet dispensing systems can be used in robot-assisted surgeries to selectively apply medications or biomaterials, for example.
3D printing can be used in medicine to manufacture customized medical products such as prostheses, implants, or organs.
Dispensing systems can be used in 3D printing in medicine to precisely dose biocompatible materials such as hydrogels or biological materials such as cells or to create complex structures such as blood vessels or nerve pathways.
Next Generation Dispensing Systems: The Future of Point-of-Care Testing
Next gen dispensing systems play a critical role in the future of point-of-care testing. They enable more precise, more flexible and more efficient testing, improving patient care. Automated dosing of samples can reduce errors and achieve reproducible results.
Hamilton Freiburg is a leading provider of next-generation dispensing solutions, offering a wide range of products and services for medical diagnostics, research, and development. Hamilton Freiburg technology includes microfluidic systems, dispensers, automation workstations and customized solutions for point-of-care diagnostic production.
These systems are not only more powerful and accurate than traditional manual methods, but also easier to use and maintain due to the use of consumable dispensing components. They enable precise dosing of fluids and are capable of automatically generating complex mixtures. The use of dispensing systems can optimize medical processes, saving time and costs.
With image processing-based process control systems, you are supported in setting the optimal conditions and proving process performance.
At Hamilton Freiburg, we have the ability to offer customized solutions for specific customer requirements. We work closely with our customers to understand individual needs and develop tailored solutions that meet their specific needs. This allows our customers to work more efficiently and effectively, achieving progress faster.
As part of the Hamilton family, Hamilton Freiburg offers the most precise and accurate liquid dispensing technology. With unique solutions tailored to your application, you can automate your workflows. Fluid-independent, contactless, production-optimizing, and limitless.